Applications

Bioscience and Medical Diagnosis
  • Detection of subtle changes within biomolecules, such as drug interactions, tissue healing, cosmetics, disease diagnosis
  • Intercellular SERS localization and interaction, identification of drug binding to cells for Drug-DNA and cellular interaction analysis
  • Investigation of microorganisms in single cells; yeast cell classifications, single bacterium
  • Molecular level cancer detection (cervical, lung, etc.)
  • Cardiovascular disease diagnosis (atherosclerosis)
Forensic Analysis
  • Nondestructive drug and narcotic drug identification
  • Explosives: exact chemical compositions of materials, PETN, RDX and binding agents within explosive materials
  • Identification and analysis of toxic solvents and bio-warfare agents
  • Forensic evidence analysis and tracing, including fibers, fabrics, pigments, inks, etc., by Raman microscopy
Raman Microscopy
  • Pharmaceutical drug analysis: micro-Raman and localized molecular species analysis in complex drug mixtures, such as beta-carotene in multivitamins
  • Material science thin film analysis, such as diamond film quality characterization
  • Trace forensic evidence analysis, including fibers, fabrics, pigments, inks, etc.
Semiconductor & Solar Industry
  • Characterization of silicon crystallinity: monitoring of the Raman band shift as silicon crystallinity changes from amorphous to a polycrystalline structure
  • Analysis of micron sized particles in situ to provide information on potential contamination
  • Mechanical stress monitoring for semiconductor process
Environmental Science
  • Water pollution detection using SERS technology
  • Identification of contaminants in water
  • Petrochemical analysis
  • Identification and analysis of sediments in water
Pharmaceutical Industry
  • Analysis of tablets, liquids, and gel caps
  • High throughput screening techniques
  • Crystallization, end point detection
  • Process Analytical Technology (PAT) on-line, at-line monitoring and control: real-time monitoring of drying, coating, and blending
  • Identification and analysis of API, additives, and excipients
  • Drug identification control: purity and quality
  • Raw material inspection: 100% incoming material identification and verification
Gemology
  • Non-invasive gemstone identification and examination
  • Identification of unknown gemstone by unique Raman signal
  • Identification of isomorph or subspecies of gemstone
  • Analysis of gemstone origin through Raman microscopy
  • Anti-counterfeiting, such as identification of diamond from zircon
Polymers and Chemical Processes
  • Quality Control: incoming/outgoing
  • Identification of contaminants during manufacturing
  • Real time monitoring of polymerization
  • Predicting the morphological properties of polymers
  • Multivariate analysis/chemometrics to predict physical properties: glass transition temperature, crystallization temperature, etc.
  • Chemical composition analysis
Geology and Mineralogy
  • Identification of geological materials
  • Examination of inclusions in minerals
  • Analysis of cement clinker by Raman microscopy
  • Ancient fossil analysis
Food & Agriculture Industry
  • Measurement of unsaturated fatty acid in food oils
  • Detection of bacteria and/or contaminants in food products
  • Identification of additive drugs: nutraceuticals in fruit drinks
  • Analysis of components in grain kernel